Cloned (Comment) | Organism |
---|---|
gene CGAS, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one | RU-521 or RU.521 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
micronucleus | telomeric DNA and cGAS are co-localized in a limited number of micronuclei | Homo sapiens | 31040 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | Homo sapiens | overall reaction | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N884 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BEAS-2B cell | - |
Homo sapiens | - |
fibroblast | immortalized 82-6 fibroblasts | Homo sapiens | - |
HT-1080 cell | - |
Homo sapiens | - |
IMR-90 cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | overall reaction | Homo sapiens | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGAS | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | cellular intrinsic mechanism involving the cGAS-mediated cytosolic self-DNA-sensing pathway that initiates premature senescence independently of telomere shortening, overview. Micronuclei generated in response to telomeric DNA replication stress recruit cGAS and cause cellular senescence | Homo sapiens |
physiological function | dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase. Cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chromatin fragments and then activating the stimulator of interferon genes (STING) cytosolic DNA-sensing pathway and downstream interferon signaling. Significantly, genetic and pharmacological manipulation of cGAS not only attenuates immune signaling, but also prevents premature cellular senescence in response to dysfunctional telomeres. cGAS causes premature senescence phenotype in response to dysfunctional telomeres, cGAS-STING-TBK1-IRF3 signaling, mechanism, overview | Homo sapiens |